Cazorla has not featured for the Gunners since October 2016 due to a series of problems with his Achilles.
Since playing in a Champions League game against Ludogorets, the midfielder has been forced to go under the knife nine times in just 14 months.
The 32-year-old was set for a comeback in January but those plans were once again pushed back after it was revealed he needed yet another round of surgery.
Having undergone the procedure on Monday, Cazorla’s return date remains a mystery but Wenger optimistically claimed he could be in line for a February comeback should all go to plan.
‘I sent him a message because he had surgery and wished him well,’ Wenger said. ‘He (Cazorla) answered “I have to start again from zero”.
‘It’s very sad. What Santi has gone through is unbelievable. It’s really, really sad. But unfortunately he has to start again from zero.
‘If all goes well he has to wait until he starts to run and after he starts to run it takes six weeks to come back to training.
‘When he can start to run again I don’t know. I was hopeful of January, but after this setback certainly now not before February.’