United came away from Spain with a 0-0 draw a fortnight ago but must beat Sevilla to progress to the last-8.
However, Ferdinand says the aggregate score is risky and urged the Red Devils to deploy ‘old school English’ tactics and play at pace against Sevilla.
‘0-0 is dangerous. United have to come out of the blocks firing, come out and try bully this team,’ Ferdinand told BT Sport.
‘Play at a fast, old school English type of pace. Don’t play slow pass it here, pass it there, be direct, make them defend, and be clinical.
‘They should be rocking. There will be a confidence and swagger. There’s been a lot of negative stuff said about United.
‘As a team, bar Man City, United have had a good season, where they are in the league, cup competitions and still in the UCL.’
United last made the last-8 in 2014 when the club were knocked out by Pep Guardiola’s Bayern Munich 4-2 on aggregate.
The Red Devils face Brighton at Old Trafford on Saturday for a place in the semi-finals of the FA Cup.