Once we hit 40, the descriptors used for skin typically have a negative connotation—words we don’t necessarily want to associate with our once bouncy, smooth complexions. According to Dendy Engleman, MD, skin becomes “dull-looking,” uneven, and wrinkles are more predominant. This is mostly due to something called perimenopause (or the years leading up to menopause), during which your estrogen levels begin to decrease and skin becomes thin and loses its elasticity. Of course, the aging process is natural, beautiful, and a privilege, but many signs of skin degradation can actually be avoided by taking preventative measures and using the right products at the right time. To find out how to make skin look its best for as long as possible, we spoke with Engelman and Gervaise Gerstner, MD.